The ships begin to move to Alaska to begin the season in April and some move in early May. Most make a stop on the west coast. Some at Long Beach or Los Angeles, some in San Diego and others head up to San Francisco before making a final leg to Seattle or Vancouver. So if you want to do the Panama canal and Alaska you'll need multiple legs. One through the canal, one up the CA coastline and the final being the first 7 day itin to Alaska. That would be a great trip!