Chris, Also keep in mind that you will need to be able to easily handle your luggage. Depending on the exact location of your hotel you will possible need to carry your luggage several blocks and go up and down over one or more pedestrian bridges. Once at the pier you will need to carry (or roll) your luggage onto the dock and eventually get it all on the boat while you are possibly surrounded with lots of other folks. The alternative in Venice is that some folks will hire a porter to carry their luggage, but this is pricy. As long as you can handle your luggage the Alilaguna (I finally spelled it right this time
) is a great option. Your hotel will be able to give you the exact location of the dock (there are several docks at St Marks Square) and check the current schedule in case it has changed.