Try Hotel Olimpia,
nicely located where the cruise ship transfers or taxis drop you off. A short walk to the train station and several taxis available to take you to the airport. The hotel is clean, can be expensive this late in the game if making a reservation, the staff is courteous and helpful. Nice Continental Breakfast; good restaurants nearby.
Hotel in Venice Hotel Olimpia Venice | Official Site | 3 star hotel Piazzale Roma Venice