It may be difficult, as driving back from Anchorage to Seattle or Vancouver is a VERY long drive, through much remote countryside, on a road that often has some rough spots - though not as bad as the 1500 miles of gravel it used to be! The biggest difficulty, however, would be that the drive involves crossing an international border (US/Canada) at least once, and twice if you are heading for Seattle. Rental car companies are often reluctant to allow cars to cross state borders, let alone international ones.
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