I'm sure we will - we always have a good time whenever we get together.
For my immediate family (DH and 2 DSs) this will be our first "big" cruise. DH and I did a barge cruise in France with 6 members of his family in 2004. "Barge" does not describe the luxury of that vessel. 8 passengers and 4 crew who catered to our every whim. It was glorious!
I'm sure that was nothing like what this cruise will be, but having done that we don't feel like total novices. Our cabin on that boat was probably 7' X 15', but so well-planned that it didn't feel cramped at all. Floating down the Canal du Midi for 6 days and seeing the sites in the south of France was a once-in-a-lifetime experience!