Glad you got the hotel you wanted, Kate. Growing up in New York, I used to visit the Museum of Natural History on field trips from school, and we'd have to write a report on what we saw. I definitely prefer visiting as an adult.
I'm a bit confused about the location of your hotel. The Museum is on Central Park West around W. 80th Street, about 20 blocks from Central Park South (CPS is a portion of 59th Street.) Or, do you have one hotel booked pre-cruise and a different one post-cruise? Both are great areas, BTW.