I wouldn't count on being able to upgrade once on board. The handicap cabins probably fill up before the cruise sails.
The "motion" you will get doesn't really depend on interior or exterior but on deck and location on the ship. For the least amount of "motion" choose cabins on the lower decks near the center of the ship.... But the ship IS moving, there is going to be some motion.
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Carnival Cruise Lines:
Fantasy 90, Celebration 95, Victory 05, Conquest 05, Spirit 6/06, Freedom 6/08, Holiday 7/08, Victory 6/09, Valor 9/09, Dream 6/10, Splendor 8/10,Conquest 8/11,Magic 11/11,Triumph 4/12,Spirit 7/12,Freedom 11/12, Triumph 2/13 - The fire cruise
NCL Dream October 2006, RCCL Mariner OTS June 2007
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